anti-nociceptive effect of the fruit essential oil of cuminum cyminum l. in rat

نویسندگان

محمد سیاح

mohammad sayyah افشین پیروی

afshin peirovi محمد کمالی نژاد

mohammad kamalinejad

چکیده

cuminum cyminum linn. (umbelliferae) is a plant, which has been used as a toothache remedy in folk medicine of iran. in this study, the potential anti-nociceptive and anti-inflammatory activities of the fruit essential oil of c. cyminum has been evaluated in chemical (formalin test) and thermal (tail-flick test) models of nociception and formalin model of acute inflammation in rats and mice. the essential oil at the doses ranging between 0.0125 and 0.20 ml/kg exhibited a significant and dose-dependent analgesic effect in the model of chronic and inflammatory pain. however, the essential oil was devoid of anti-inflammatory activity. moreover, the essential oil had no analgesic effect in tail flick test as a model of acute pain. the ld50 value of 0.59 ml/kg was obtained for the essential oil. this low toxicity of the essential oil makes it worthy for further studies

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Anti-Nociceptive Effect of the Fruit Essential Oil of Cuminum cyminum L. in Rat

Cuminum cyminum Linn. (Umbelliferae) is a plant, which has been used as a toothache remedy in folk medicine of Iran. In this study, the potential anti-nociceptive and anti-inflammatory activities of the fruit essential oil of C. cyminum has been evaluated in chemical (formalin test) and thermal (tail-flick test) models of nociception and formalin model of acute inflammation in rats and mice. Th...

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عنوان ژورنال:
iranian biomedical journal

جلد ۶، شماره ۴، صفحات ۱۴۱-۱۴۵

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